Friday 14th SATELLITE SYMPOSIUM
Roni Lara Moya
Title: Regenerative Biomedicine and Xenogeneic Cell Therapy in Immune Rejuvenation
With aging comes a remodeling of the immune system. Over time, this leads to a decline in immune effectiveness, resulting in increased vulnerability to infectious diseases, decreased vaccination responses, and susceptibility to age-related inflammatory diseases. This phenomenon, called immunosenescence, is multifactorial and affects both natural and acquired immunity. As aging is a plastic process, it is influenced by both nutritional and pharmacological interventions. Regenerative biomedicine aims to use cutting-edge technology specialized in cell therapy and tissue-derived peptides; as well as their regenerative factors to combat immunosenescence and rejuvenate the immune system. The purpose of this conference is to develop the basic concepts on cell therapy in biomedical clinical practice for immune rejuvenation.
Roni Lara Moya Is an immunologist with specialization in Anti-aging and Regenerative Medicine. Professor and Scientific Investigator at the International University of BioRegenerative Sciences (IUBRS) in the- United States, a Biomedical Consultant of the EuropeanWellness Academy (EWA), as well as an Executive and Scientific Director of Regenera – Regenerative Biomedicine; Lisbon
Title: Mitochondrial Cell Therapy in Anti-Aging Practice
Mitochondrial degeneration has been shown to be the major cause of age-related deterioration and scientific reports concluded that the tissues of a 70-year-old man contained 95% damaged mitochondria compared to almost no damage in that of a 5- year-old child. Hundreds of scientific papers link defective mitochondria to virtually all degenerative diseases such as Alzheimer’s, diabetes, cardiovascular disease, obesity and cancer. Cell therapy is a regenerative biomedical treatment based on the combination of peptides, amino acids, proteins, growth factors, transcription factors and hormones derived from cellular tissues with the aim of biochemical, metabolic and immunological modulation as well as cellular restoration. Being a fusion of cell therapy and mitochondrial medicine, mitochondrial organelle cell therapy includes a range of peptides that broadens the horizons of therapeutic rejuvenation and creates new opportunities for aesthetic and anti-aging practitioners. Mitochondrial peptides contain an immaculate blend of cellular peptides, predominantly specific to mitochondria, extracted to ensure rapid cell regeneration and restoration of normal function. The aim of this talk is to present the potential for clinical use of mitochondrial cell peptides in anti-aging and regenerative practice.
Title: Male hormonal optimization protocols in anti-aging and longevity medicine
The recent research and longitudinal clinical trials allowed to expand the understanding of the significance and clinical relevance of Hypogonadism in development and occurrence of frailty syndrome, sarcopenia, osteopenia, obesity, metabolic syndrome, cardiovascular disease, and age-related cognitive decline. Sufficient data has been accumulated and analysed to establish the causation and correlation between the decline of sex hormones and other parameters of metabolic health. The modern therapeutic paradigms for Late Onset Hypogonadism (LOH) are based on employing the combination of two strategies: the stimulatory therapy and replacement therapy, resulting in effective and safe in the long-term Hormonal Optimization Protocols, which are presented in the current lecture-presentation in detail. The choice of therapeutic products, dosages, duration of the treatment, as well as criteria of successful outcome and dynamic follow-up of the patients are thoroughly discussed in the current lecture-presentation. Scientific and research data is additionally supported by clinical cases presentation and analysis from the actual clinical experience of the presenter. The lecture-presentation contains practical recommendations for medical practitioners and addresses a vast audience of general health practitioners, anti-aging doctors, wellness experts, endocrinologists and biohackers.
Dmytro Klokol, MD, PhD (Ukraine), European Wellness Retreat (Malaysia), European Wellness Academy
Title: The role of cell therapy in biological regenerative medicine, wellness, anti-aging and longevity medicine
Preventive medicine, wellness and longevity medicine still remain underrated and considered by many as either auxiliary or luxury enterprise. The biological basis of regenerative medicine is based on the stimulation of patient’s potential to tissue regeneration and prevention/reversal of organs’ degeneration with the ultimate goal of maintenance of the healthy state, unlike the conventional reductionist approach focusing on the elimination of symptoms and dealing with the consequences of disease. Biological regenerative medicine targets the organism’s ability to self-regulate and regenerate, to adapt to the constantly changing environment; hence it is able to maintain the Wellness, instead of removing the symptoms only. The recent scientific discoveries in regenerative medicine substantiates a number of therapeutic modalities namely senolytic therapies, activation of AMPK pathways, SIRT genes, modulation of epigenetic status, reduction of chronic systemic inflammation, re-activation of mitochondrial function, alleviation of insulin resistance and many others. It is crucial to employ a programmatic and personalized approach to managing the health of the individual. The ultimate benefit of the programmatic approach provides a higher degree of certainty to achieve better and more consistent outcomes across cost, risk and long-term performance status and well-being for each individual under care. The current lecture-presentation highlights main aspects of therapeutic paradigms employed by anti-aging and longevity medicine.
Title: Healthy gut delays neurodegeneration
Recent research suggests the critical role of the intestinal microbiome in neurodegeneration. The gut microbiota produces important metabolites, which are involved in interconnections with the host. This physiological cooperation is also known as “gut–brain axis”. The link between the gut microbiota and the neurodegenerative diseases, such as cognitive impairment and Alzheimer’s disease, are well outlined. Besides the microbiome, the enteric integrity also determines the local and systemic immune response, cognitive, emotional, and hormonal profile of a human. In our presentation, we will discuss the role of the intestinal mucosa to transmit signaling molecules and metabolites of bacterial origin to the brain, immune system, and endocrine organs. Also, we will outline the potential ways to rejuvenate the anatomy and functions of intestine.
Dr. Yuriy Nalapko, MD, PhD, JD, is the Senior Medical Advisor for European Wellness International Group. His PhD research in Luhansk State Medical University (Ukraine) was devoted to the intensive care of the brain disorders. Also, in Imperial College London (UK) he studied the mechanisms of the interaction of a patient and microflora in ICUs. Currently, his research and medical practice are focused on the mechanisms of longevity, ageing and antiageing. He is a medical consultant for some clinics in Europe and Asia.
Prof. Dr. Thomas Skutella (Heidelberg Uni)
Title: A stress-induced cellular anti-aging model of fetal stem-cell peptides of Mito Organelles from lung and placenta on HEK and HEPG2 cells in senescence in vitro model
Aging refers to the physical and functional decline of the tissues over time that often leads to age-related degenerative diseases. We have utilized a model of stress-induced senescence (Hydrogen peroxide treatment protocol) and effectively induced HEK and HepG2 cells to undergo cellular senescence as determined by augmented senescence-associated-b-galactosidase (SA-b-gal) staining, decreased proliferation and differentiation capacity and elevated reactive oxygen species (ROS) level. The phenotypic changes were accompanied by a significant increase in p16, p21, and p53 expression and a decreased expression of critical proteins in various DNA repair pathways. Treatment of the cells during stress-induced senescence significantly with Mito Organelles (MO) characterized by proteomics from the placenta and lung reduced all markers of cellular senescence in HEK and HepG2 cells. Taken together, we have successfully demonstrated the functional impact of MOs within a molecular exploration of senescence and aging in vitro.
Prof. Dr. Thomas Skutella (Heidelberg Uni)